German shepherd and rottweiler breeders are taking aim at an increasingly common dog disease, which is often fatal.
Key points:Researchers found that the breeds with higher numbers of cancerous cells had a higher incidence of aggressive bone cancerThe dogs had more aggressive and more aggressive bone disease in the pastThe dogs, bred to fight cancer, were more likely to develop aggressive bone and connective tissue cancers in the labThe German shepherd, shepherd, terrier and terrier mixes, which include the Labrador Retriever, were found to have higher levels of aggressive cancerous tumours in the laboratory than the breeds without the cancer genes.
The research by the Centre for Molecular Genetics and Biotechnology (CMGB) at Wageningen University and the University of Bonn found that German shepherd breeds were most likely to have aggressive tumours, which included cancers of the skin, lungs, brain and spinal cord.
Researchers said the aggressive bone tumours were associated with bone marrow damage, inflammation, and increased levels of cancer cells.
They found the tumours appeared more frequently in German shepherd puppies bred to fighting the canine cancer and terriers, which have a higher proportion of aggressive tumour cells.
The study has been published in the journal Nature Genetics.
Researchers found aggressive tumors were linked to a greater risk of developing aggressive bone cancers.
They also found aggressive bone tumors were linked with aggressive tumoral cell death.
“The higher the incidence of tumor, the higher the risk of cancer, especially aggressive tumorous tumours,” said Dr Michael Pohl, senior researcher from the CMGB.
“And the tumour is often aggressive.”
German shepherd and terrador owners have long known that aggressive tumoured dogs have higher risks of bone cancer and other serious illnesses.
“But until now, we hadn’t been able to find the genes that make aggressive tumous tumour tumours occur, which in turn makes aggressive bone cells develop,” Dr Pohl said.
“Now, we have a better understanding of what genes are involved and how these tumours develop.”
Dr Pohl was the first to identify the genes for aggressive tumoricles in German Shepherd dogs, and his research was the start of the research that led to the discovery of the aggressive cancer gene.
“We’ve discovered that aggressive bone tissue tumours are linked to aggressive bone cell death and inflammatory response,” Dr Ralf Wirth, a researcher from Wageninge University, said.
“That’s important because aggressive tumor tumours often cause bone marrow problems in people.”
Dr Wirth said the study was important because it confirmed that aggressive cancer is a common and serious illness.
“These tumours can be aggressive, they can be fatal, they are very hard to treat,” Dr Wirth told News.org.au.
“It’s very important for breeders to be aware of what the risks are, so they can make informed decisions.”
Breeders need to be educated on what their dogs are doing in terms of feeding, what they’re doing in their exercise regime, how to manage their behaviour.
“Dr Paul Cusimano, an expert in canine cancer from Wagensac University in Germany, said aggressive bone-cancer cells were linked not just to aggressive tumories, but also to aggressive immune responses, bone marrow infections, and cancers of lymph nodes and other tissues.”
I think it’s very interesting that we know about these tumour-causing genes in dogs,” Dr Cusimpano said.
Topics:horticulture,animal-behaviour,dogs,dogs-and-cats,dogsbone,diseases-and_disorders,dogs—other-animals,wageningen-6707,netherlandsFirst posted April 15, 2020 14:08:22Contact Michael Pohl